Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908668 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL607171 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL18716191 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL13194131 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL19116931 | 0.80 | TP53 (0.52) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL23665086 | 0.80 | KMT2A (0.56) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL18199495 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL20340484 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL22054929 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL18674311 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53HPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236775-A1 | SMALL MOLECULE DEGRADERS OF SHP2 PROTEIN | THE REGENTS OF THE UNIVERSITY OFMICHIGAN (US) | 2021-11-25 | — | — | WO | disclosed |