Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17646019 | 0.82 | BTK (0.48) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL20878550 | 0.82 | BTK (0.46) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17646000 | 0.82 | BTK (0.48) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL27457324 | 0.81 | BTK (0.53) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17646021 | 0.80 | BTK (0.49) | BTKLCK | |
| SCHEMBL21207730 | 0.80 | BTK (0.44) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL24061690 | 0.79 | BTK (0.51) | BTKLCK | |
| SCHEMBL30950575 | 0.78 | BTK (0.59) | BTKLCK | |
| SCHEMBL17645701 | 0.78 | BTK (0.59) | BTKLCK | |
| SCHEMBL17645888 | 0.78 | BTK (0.73) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204382-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-12-01 | — | — | EP | disclosed |