Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17645973 | 0.86 | BTK (0.65) | BTKEPHX2NR1H4 | |
| SCHEMBL24061526 | 0.86 | BTK (0.55) | BTK | |
| SCHEMBL17645673 | 0.80 | BTK (0.80) | BTKLCK | |
| SCHEMBL17645837 | 0.77 | BTK (0.79) | BTKLCK | |
| SCHEMBL17645914 | 0.77 | BTK (0.62) | BTKEPHX2NR1H4LCK | |
| SCHEMBL17646017 | 0.77 | BTK (0.56) | BTKEPHX2NR1H4LCK | |
| SCHEMBL17645814 | 0.76 | BTK (0.57) | BTKEPHX2NR1H4LCK | |
| SCHEMBL17660316 | 0.75 | BTK (0.80) | BTKEPHX2NR1H4 | |
| SCHEMBL17645953 | 0.74 | BTK (0.55) | BTKEPHX2NR1H4LCK | |
| SCHEMBL17660351 | 0.74 | BTK (0.53) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204382-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-12-01 | — | — | EP | disclosed |