Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17645780 | 0.90 | BTK (0.42) | BTKCBFBFFAR1PDE10ARPS6KA3 | |
| SCHEMBL17645674 | 0.81 | BTK (0.63) | BTK | |
| SCHEMBL17646059 | 0.80 | BTK (0.68) | BTK | |
| SCHEMBL24061607 | 0.80 | HTR2C (0.39) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL17660347 | 0.79 | BTK (0.43) | BTKRPS6KA3MAPK14 | |
| SCHEMBL17646003 | 0.79 | MAPK14 (0.42) | BTKRPS6KA3MAPK14 | |
| SCHEMBL17645984 | 0.79 | MAPK14 (0.42) | BTKRPS6KA3MAPK14 | |
| SCHEMBL17660360 | 0.78 | BTK (0.47) | BTKCBFBPDCD1LG2CD274MAPK14 | |
| SCHEMBL17645988 | 0.78 | BTK (0.56) | BTKCBFB | |
| SCHEMBL24061705 | 0.77 | BTK (0.58) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204382-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-12-01 | — | — | EP | disclosed |