Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Atropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.91 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.91 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.91 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.91 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.91 |
| ▸ | LMNA | P02545 | 3/20 | 0.91 |
| ▸ | HTR2C | P28335 | 2/20 | 0.91 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.91 |
| ▸ | BLM | P54132 | 2/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.91 |
| ▸ | MEN1 | O00255 | 1/20 | 0.91 |
| ▸ | POLB | P06746 | 1/20 | 0.91 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.91 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.91 |
| ▸ | HRH1 | P35367 | 1/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.91 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atropine SCHEMBL27510472 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL3050622 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL28275981 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Endo-Atropine SCHEMBL29555014 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Hyoscyamine SCHEMBL34273 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL1411666 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL31133 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL31132 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL34274 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 | |
| Atropine SCHEMBL34275 | 1.00 | MAPT (1.00) | MAPTALDH1A1CHRM1CHRM2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212090-A1 | Combinatorial Analysis and Repair | DAKO DENMARK A/S | 2011-09-01 | — | — | US | disclosed |