Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.52 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27667113 | 0.80 | IKBKB (0.50) | IKBKETBK1MAP4K4MAP2K4MAPT | |
| SCHEMBL488290 | 0.78 | IKBKE (0.59) | IKBKETBK1SGK1CAMKK2CA12 | |
| SCHEMBL5543060 | 0.77 | MKNK1 (0.65) | IKBKETBK1SGK1CAMKK2CA12 | |
| SCHEMBL29124905 | 0.77 | IKBKE (0.58) | IKBKETBK1SGK1CAMKK2CA12 | |
| SCHEMBL38655263 | 0.77 | ERN1 (0.51) | IKBKETBK1SGK1CAMKK2CA12 | |
| SCHEMBL23226712 | 0.77 | CA1 (0.56) | CA12CA1CA2CA9CA14 | |
| SCHEMBL38657217 | 0.76 | ERN1 (0.56) | CA12CA1CA2CA9CA14 | |
| SCHEMBL15614634 | 0.75 | ERN1 (0.52) | IKBKETBK1SGK1CAMKK2CA1 | |
| SCHEMBL38655297 | 0.75 | ERN1 (0.59) | IKBKETBK1SGK1CAMKK2CA12 | |
| SCHEMBL19025784 | 0.75 | SGK1 (0.54) | IKBKETBK1SGK1CAMKK2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167114-A1 | MACROCYCLIC JAK INHIBITOR AND USE THEREOF | BIOPOLAR HONGYE (NANTONG) PHARMACEUTICAL CO. LTD. (CN) | 2023-06-01 | — | — | US | disclosed |
| US-20230167114-A1 | MACROCYCLIC JAK INHIBITOR AND USE THEREOF | BIOPOLAR HONGYE (NANTONG) PHARMACEUTICAL CO. LTD. (CN) | 2023-06-01 | — | — | US | disclosed |
| WO-2021238817-A1 | MACROCYCLIC JAK INHIBITOR AND USE THEREOF | 百极弘烨（广东）医药科技有限公司 | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167114-A1 | MACROCYCLIC JAK INHIBITOR AND USE THEREOF | JAK1, JAK2, JAK3 | IKBKE 11/4885TBK1 177/4885SGK1 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.