Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.46 |
| ▸ | JAK3 | P52333 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23878875 | 0.89 | TYK2 (0.58) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22054023 | 0.89 | TYK2 (0.58) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22055241 | 0.89 | TYK2 (0.48) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22054585 | 0.89 | TYK2 (0.49) | TYK2JAK3JAK1JAK2NTRK1 | |
| SCHEMBL22055237 | 0.88 | TYK2 (0.57) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL22054191 | 0.85 | TYK2 (0.50) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22055052 | 0.84 | TYK2 (0.52) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22055174 | 0.84 | TYK2 (0.53) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL23878864 | 0.83 | TYK2 (0.59) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL22054033 | 0.83 | TYK2 (0.59) | TYK2JAK3JAK1JAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021238908-A1 | SALT AND CRYSTAL FORM OF HETEROARYL DERIVATIVE, AND PREPARATION METHOD THEREFOR | 上海翰森生物医药科技有限公司 | 2021-12-02 | — | — | WO | disclosed |