Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.51 |
| ▸ | JAK3 | P52333 | 13/20 | 0.51 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | OPA1 | O60313 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | STAT5A | P42229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24072054 | 0.94 | JAK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL24072059 | 0.87 | JAK2 (0.54) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12921635 | 0.84 | JAK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12921636 | 0.83 | JAK2 (0.47) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12948369 | 0.82 | JAK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL14727993 | 0.81 | JAK2 (0.48) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12948320 | 0.81 | JAK2 (0.48) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12948473 | 0.80 | JAK2 (0.54) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12921637 | 0.80 | JAK2 (0.46) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12921646 | 0.79 | JAK2 (0.48) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203059-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | BIOPOLAR HONGYE (NANTONG) PHARMACEUTICAL CO. LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| WO-2021238818-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | 百极弘烨（广东）医药科技有限公司 | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203059-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | JAK3, JAK2, JAK1 | JAK2 2/4885JAK3 1/4885JAK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.