Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 14/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | CCNK | O75909 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CCND3 | P30281 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.56 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25838551 | 0.90 | AXL (0.62) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL21446899 | 0.90 | AXL (0.57) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL25839353 | 0.90 | AXL (0.62) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL21446898 | 0.88 | AXL (0.69) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL25838913 | 0.87 | AXL (0.54) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL25838868 | 0.86 | AXL (0.53) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL22872058 | 0.85 | AXL (0.71) | AXLAURKBAURKAALKJAK2 | |
| SCHEMBL25838760 | 0.84 | NTRK1 (0.51) | AXLAURKBAURKAALKJAK2 | |
| Dubermatinib SCHEMBL29394359 | 0.82 | AXL (1.00) | AXLAURKBAURKAALKJAK2 | |
| Dubermatinib SCHEMBL12813478 | 0.82 | AXL (1.00) | AXLAURKBAURKAALKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023093859-A1 | SALT OF AXL KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 南京正大天晴制药有限公司 | 2023-06-01 | — | — | WO | disclosed |
| WO-2023093861-A1 | MONO-P-TOLUENESULFONATE OF AXL KINASE INHIBITOR AND CRYSTAL FORM THEREOF | 南京正大天晴制药有限公司 | 2023-06-01 | — | — | WO | disclosed |
| WO-2021239133-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | 南京正大天晴制药有限公司 | 2021-12-02 | — | — | WO | disclosed |