Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | GPR4 | P46093 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25169698 | 0.84 | USP2 (0.43) | USP2SMN1; SMN2EPHX2EPHX1TSHR | |
| SCHEMBL16553663 | 0.81 | USP2 (0.44) | USP2SMN1; SMN2EPHX2HPGDCYP11B2 | |
| SCHEMBL24012274 | 0.81 | USP2 (0.44) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL9773945 | 0.80 | USP2 (0.42) | USP2SMN1; SMN2EPHX2HPGDCYP11B2 | |
| SCHEMBL3332689 | 0.80 | USP2 (0.42) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL3031720 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2EPHX2EPHX1TSHR | |
| SCHEMBL3318268 | 0.80 | CYP4F2 (0.45) | USP2SMN1; SMN2EPHX2HPGDCYP11B2 | |
| SCHEMBL3314428 | 0.80 | SMN1; SMN2 (0.41) | USP2SMN1; SMN2EPHX2TSHRHPGD | |
| SCHEMBL24752804 | 0.78 | USP2 (0.45) | USP2SMN1; SMN2EPHX2EPHX1TSHR | |
| SCHEMBL31447849 | 0.78 | USP2 (0.41) | USP2SMN1; SMN2EPHX2HPGDHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166142-B | Five-membered and six-membered heterocyclic compounds and application thereof as protein receptor kinase inhibitors | 上海轶诺药业有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-3919490-A1 | FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR | Shanghai Ennovabio Pharmaceuticals Co., Ltd. (CN) | 2021-12-08 | — | — | EP | disclosed |
| CN-113242857-A | Preparation and application of imidazo aromatic ring compounds | 上海轶诺药业有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-113166142-A | Five-membered and six-membered heterocyclic compounds and application thereof as protein receptor kinase inhibitors | 上海轶诺药业有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-111171019-A | Five-membered and six-membered heterocyclic compounds and application thereof as protein receptor kinase inhibitors | 上海轶诺药业有限公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-111039946-A | Preparation and application of imidazo aromatic ring compounds | 上海轶诺药业有限公司 | 2020-04-21 | — | — | CN | disclosed |