Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 7/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 5/20 | 0.36 |
| ▸ | CCNH | P51946 | 5/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509264 | 1.00 | CCNK (0.43) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21188524 | 0.89 | HDAC4 (0.38) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509209 | 0.89 | HDAC4 (0.38) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL24087439 | 0.88 | CCNT1 (0.44) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509173 | 0.88 | CCNT1 (0.44) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509342 | 0.86 | USP30 (0.42) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30976716 | 0.80 | MAPK8 (0.41) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30204047 | 0.79 | CCNK (0.51) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL21178482 | 0.78 | MAPK3 (0.37) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30203949 | 0.78 | CDK7 (0.42) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311542-B2 | Inhibitors of cyclin dependent kinase 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210379065-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11311542-B2 | Inhibitors of cyclin dependent kinase 7 (CDK7) | CDK7, CDK3, CCNK | CCNK 3/4885CDK12 27/4885CCNE1 48/4885 |
| US-20210379065-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CCNK | CCNK 3/4885CDK12 27/4885CCNE1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.