Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921839 | 0.76 | JAK2 (0.41) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL26074490 | 0.74 | CD274 (0.50) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL22128054 | 0.72 | JAK2 (0.48) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL25245334 | 0.70 | JAK2 (0.49) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL25753037 | 0.69 | JAK2 (0.43) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL26233608 | 0.69 | JAK2 (0.43) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL30587023 | 0.69 | JAK2 (0.41) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL26618969 | 0.69 | JAK2 (0.41) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL17459842 | 0.68 | JAK2 (0.41) | MAP3K5JAK2JAK1TYK2JAK3 | |
| SCHEMBL1343572 | 0.68 | JAK2 (0.41) | MAP3K5JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157831-B1 | PROCESSES OF PREPARING A JAK1 INHIBITOR | INCYTE CORP (US) | 2024-10-30 | — | — | EP | disclosed |
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | INCYTE CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | INCYTE CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | INCYTE CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| EP-4157831-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR | Incyte Corporation (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115836065-A | Methods of making JAK1 inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| US-20210380563-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR | INCYTE CORPORATION | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | JAK1, JAK2, JAK3 | MAP3K5 60/4885JAK2 2/4885JAK1 1/4885 |
| US-20210380563-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR | JAK1, JAK2, JAK3 | MAP3K5 60/4885JAK2 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.