Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 19/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MC5R | P33032 | 1/20 | 0.47 |
| ▸ | MC3R | P41968 | 1/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094617 | 1.00 | MC4R (0.77) | MC4RKCNH2MC5RMC3RFASN | |
| SCHEMBL24094728 | 0.87 | MC4R (0.77) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL25205868 | 0.87 | MC4R (0.77) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL31139092 | 0.87 | MC4R (0.77) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL24940930 | 0.87 | MC4R (0.77) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL24940753 | 0.87 | MC4R (1.00) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL24939963 | 0.87 | MC4R (1.00) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL24940672 | 0.87 | MC4R (1.00) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL25421472 | 0.87 | MC4R (1.00) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL24939959 | 0.87 | MC4R (1.00) | MC4RKCNH2MC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021250541-A1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2021-12-16 | — | — | WO | disclosed |