Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25588054 | 0.86 | MC4R (0.41) | MC4RKCNH2MC5RMC3RMAPK1 | |
| SCHEMBL25588048 | 0.81 | MC4R (0.48) | MC4RKCNH2MC5RMC3RFFAR1 | |
| SCHEMBL25588822 | 0.74 | MC4R (0.46) | MC4RKCNH2MC5RMC3RFFAR1 | |
| SCHEMBL25588046 | 0.74 | MC4R (0.48) | MC4RKCNH2MC5RMC3RFFAR1 | |
| SCHEMBL25588015 | 0.74 | MC4R (0.38) | MC4RKCNH2MC5RMC3RFFAR1 | |
| SCHEMBL25586681 | 0.74 | MC4R (0.48) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL25588736 | 0.74 | MC4R (0.44) | MC4RKCNH2MC5RMC3RFFAR1 | |
| SCHEMBL25588857 | 0.73 | MC4R (0.44) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL25588197 | 0.72 | MC4R (0.46) | MC4RKCNH2MC5RMC3R | |
| SCHEMBL25586770 | 0.71 | MC4R (0.63) | MC4RKCNH2MC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021250541-A1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2021-12-16 | — | — | WO | disclosed |