SCHEMBL2409747 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	HRH3	Q9Y5N1	14/20	0.67

▸	KCNH2	Q12809	2/20	0.67

▸	HCRTR1	O43613	2/20	0.39

▸	HCRTR2	O43614	2/20	0.39

▸	L3MBTL1	Q9Y468	1/20	0.37

▸	CHRM1	P11229	2/20	0.37

▸	CHRM5	P08912	1/20	0.37

▸	RAB9A	P51151	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3053649	0.86	HRH3 (0.72)	HRH3KCNH2HCRTR1HCRTR2
SCHEMBL3047580	0.86	HRH3 (0.72)	HRH3KCNH2HCRTR1HCRTR2
SCHEMBL3062636	0.82	HRH3 (0.75)	HRH3KCNH2
Abt-288 SCHEMBL3691125	0.81	HRH3 (1.00)	HRH3KCNH2
Abt-288 SCHEMBL2406947	0.81	HRH3 (1.00)	HRH3KCNH2
Abt-288 SCHEMBL2409486	0.81	HRH3 (1.00)	HRH3KCNH2
SCHEMBL2410805	0.81	HRH3 (0.59)	HRH3KCNH2
Abt-288 SCHEMBL3048597	0.80	HRH3 (0.98)	HRH3KCNH2
SCHEMBL9343898	0.79	CHRM1 (0.51)	HRH3L3MBTL1CHRM1CHRM5
Abt-288 SCHEMBL3047555	0.79	HRH3 (0.96)	HRH3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8399468-B2	Octahydro-pyrrolo[3,4-B]pyrrole derivatives	ABBOTT LABORATORIES (US)	2013-03-19	—	—	US	disclosed
US-8026240-B2	Octahydro-pyrrolo[3,4-b]pyrrole N-oxides	ABBOTT LABORATORIES (US)	2011-09-27	—	—	US	disclosed