Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.67 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101625 | 0.84 | CCNK (0.78) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101742 | 0.83 | CCNK (0.72) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101439 | 0.80 | CCNK (1.00) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101693 | 0.80 | CCNK (0.70) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101422 | 0.80 | CCNK (0.83) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101721 | 0.79 | CCNK (0.73) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101425 | 0.79 | CCNK (0.66) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101442 | 0.79 | CCNK (0.81) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101719 | 0.79 | CCNK (0.81) | CCNKDDB1CDK12HTTSMN1; SMN2 | |
| SCHEMBL24101725 | 0.79 | CCNK (1.00) | CCNKDDB1CDK12HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |