Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24104651 | 0.82 | TTK (0.53) | TTKAURKAMAPKAPK5KDM4EMEN1 | |
| SCHEMBL22160262 | 0.76 | TTK (0.49) | TTKAURKAMAPKAPK5PTK6 | |
| SCHEMBL24104803 | 0.74 | TTK (0.46) | TTKAURKAMAPKAPK5PTK6 | |
| SCHEMBL22122881 | 0.74 | TTK (0.50) | TTKMAPKAPK5PTK6 | |
| SCHEMBL30168183 | 0.74 | TTK (0.46) | TTKAURKAMAPKAPK5PTK6 | |
| SCHEMBL3469261 | 0.74 | FYN (0.49) | TTKAURKAMAPKAPK5KDM4EMEN1 | |
| SCHEMBL24105239 | 0.74 | SRC (0.41) | TTKAURKAMAPKAPK5AURKBPTK6 | |
| SCHEMBL15063040 | 0.74 | MAPKAPK5 (0.69) | AURKAMAPKAPK5AURKBPTK6 | |
| SCHEMBL3469696 | 0.73 | TTK (0.50) | TTKAURKAMAPKAPK5MEN1NPC1 | |
| SCHEMBL22142987 | 0.72 | PTK6 (0.44) | TTKAURKAMAPKAPK5MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249893-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |