Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 5/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 7/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30371857 | 0.87 | PTK6 (0.46) | PTK6MC4RFYNTTK | |
| SCHEMBL25447277 | 0.87 | PTK6 (0.46) | PTK6MC4RFYNTTK | |
| SCHEMBL24105239 | 0.87 | SRC (0.41) | PAX8PTK6AURKAFYNAURKB | |
| SCHEMBL22142987 | 0.84 | PTK6 (0.44) | PAX8PTK6PIP4K2AAURKAFYN | |
| SCHEMBL24105229 | 0.83 | PTK6 (0.49) | PTK6MC4RFYNTTKGRM4 | |
| SCHEMBL30168157 | 0.83 | PTK6 (0.49) | PTK6MC4RFYNTTKGRM4 | |
| SCHEMBL22122923 | 0.82 | PTK6 (0.49) | PTK6AURKBTTK | |
| SCHEMBL30171768 | 0.82 | PTK6 (0.49) | PTK6AURKBTTK | |
| SCHEMBL24105217 | 0.82 | PTK6 (0.45) | PTK6PIP4K2AAURKAFYNAURKB | |
| SCHEMBL30168173 | 0.82 | PTK6 (0.45) | PTK6PIP4K2AAURKAFYNAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249893-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |