Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24105215 | 0.88 | SRC (0.49) | SRCTTKAURKALMNANPC1 | |
| SCHEMBL30371440 | 0.88 | SRC (0.49) | SRCTTKAURKALMNANPC1 | |
| SCHEMBL3466981 | 0.86 | SRC (0.56) | SRCTTKAURKALMNANPC1 | |
| SCHEMBL24105022 | 0.83 | TTK (0.52) | SRCTTKAURKANPC1RAB9A | |
| SCHEMBL24105202 | 0.83 | AURKA (0.55) | SRCTTKAURKAGSK3BAURKB | |
| SCHEMBL22122900 | 0.81 | TTK (0.54) | SRCTTKAURKAMAPKAPK5ALDH1A1 | |
| SCHEMBL24105039 | 0.81 | AURKA (0.70) | SRCTTKAURKASMN1; SMN2AURKB | |
| SCHEMBL8246763 | 0.80 | AURKA (0.67) | SRCTTKAURKALMNANPC1 | |
| SCHEMBL30168171 | 0.80 | EIF2AK4 (0.46) | SRCTTKAURKAAURKBMAPKAPK5 | |
| SCHEMBL5408800 | 0.80 | FLT3 (0.54) | SRCTTKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249893-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |