Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 15/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112322 | 0.95 | TTK (0.39) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL24112549 | 0.90 | PTK6 (0.36) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL30171633 | 0.88 | TTK (0.42) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL22139078 | 0.88 | TTK (0.42) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL22123436 | 0.86 | TTK (0.40) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL22125090 | 0.84 | TTK (0.39) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL22123377 | 0.84 | TTK (0.40) | TTKPTK6MAPKAPK5AURKA | |
| SCHEMBL22123796 | 0.83 | TTK (0.40) | TTKPTK6MAPKAPK5AURKA | |
| SCHEMBL22122957 | 0.83 | TTK (0.42) | TTKPTK6MAPKAPK5AURKACDK2 | |
| SCHEMBL24870981 | 0.83 | TTK (0.40) | TTKPTK6MAPKAPK5AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249896-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |