Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180574 | 0.83 | KCNH2 (0.36) | KCNH2DPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL12005354 | 0.83 | AKT1 (0.32) | ALDH1A1MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5986119 | 0.81 | SLC6A2 (0.41) | DPP8DPP9DPP7ALDH1A1CYP3A4 | |
| SCHEMBL25675781 | 0.80 | CYP3A4 (0.31) | CYP3A4 | |
| SCHEMBL26419000 | 0.80 | TMEM97 (0.33) | KCNH2KDM4E | |
| SCHEMBL2625759 | 0.78 | MEN1 (0.39) | KCNH2HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL12367362 | 0.77 | KCNH2 (0.50) | KCNH2DPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL24123817 | 0.74 | KCNH2 (0.35) | KCNH2DPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL25675807 | 0.72 | P2RY1 (0.30) | ALDH1A1 | |
| SCHEMBL11988475 | 0.72 | NOTUM (0.42) | DPP8DPP9DPP7MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021254389-A1 | PYRAZOLO[3,4-D]PYRIMIDINE-3-KETONE DERIVATIVE AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2021-12-23 | — | — | WO | disclosed |