SCHEMBL24129489

SCHEMBL24129489

CCNCCc1cn(C)cn1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 3/20 0.56
CYP2C19 P33261 2/20 0.56
HRH3 Q9Y5N1 2/20 0.56
CYP2C9 P11712 1/20 0.56
TSHR P16473 1/20 0.56
MTOR P42345 1/20 0.56
TDP1 Q9NUW8 1/20 0.55
NAMPT P43490 2/20 0.37
SIRT2 Q8IXJ6 2/20 0.33
LTA4H P09960 1/20 0.32
OGA O60502 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
SLC6A2 P23975 1/20 0.32
HTR1D P28221 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
KMT2A Q03164 1/20 0.32
PIK3CA P42336 1/20 0.31
PIK3CG P48736 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2178770 0.90 HRH4 (0.62) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL8288760 0.82
SCHEMBL13100180 0.81 CYP2C9 (0.50) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL1913121 0.81 HRH3 (0.60) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL24128076 0.80 HRH4 (0.55) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL16373631 0.79 HRH4 (0.58) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL16310140 0.79 HRH4 (0.53) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL31369584 0.78 HRH4 (0.49) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL24127755 0.76 HRH4 (0.55) HRH4CYP2C19HRH3CYP2C9TSHR
SCHEMBL24128143 0.76 CYP2C9 (0.50) HRH4CYP2C19HRH3CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021257828-A1 SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE SHY THERAPEUTICS, LLC (US) 2021-12-23 WO disclosed