Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 5/20 | 0.41 |
| ▸ | SNCA | P37840 | 3/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826254 | 0.85 | TDP1 (0.53) | ATMTDP1LMNAMAPTCYP3A4 | |
| SCHEMBL29547124 | 0.83 | ATM (0.60) | ATMTDP1LMNAMAPTBACE1 | |
| SCHEMBL564611 | 0.83 | ATM (0.60) | ATMTDP1LMNAMAPTBACE1 | |
| SCHEMBL16951913 | 0.81 | ATM (0.58) | ATMTDP1LMNAMAPTCASP6 | |
| SCHEMBL564374 | 0.81 | ATM (0.58) | ATMTDP1LMNAMAPTCASP6 | |
| SCHEMBL216553 | 0.80 | TDP1 (0.72) | ATMTDP1CASP6CYP3A4TSHR | |
| SCHEMBL29745239 | 0.80 | TDP1 (0.72) | ATMTDP1CASP6CYP3A4TSHR | |
| SCHEMBL3512659 | 0.79 | ATM (0.55) | ATMTDP1LMNAMAPTBACE1 | |
| SCHEMBL3512661 | 0.79 | ATM (0.55) | ATMTDP1LMNAMAPTBACE1 | |
| SCHEMBL11239970 | 0.78 | MAPK1 (0.58) | TDP1LMNABACE1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164509-B1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RES INC (US) | 2021-12-29 | — | — | EP | disclosed |