Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24137473 | 0.85 | KCNH2 (0.43) | KCNH2KDRFYNCYP11B2CCNE1 | |
| SCHEMBL24137475 | 0.82 | KCNH2 (0.46) | KCNH2KDRFYNCYP11B2LTA4H | |
| SCHEMBL13743125 | 0.75 | KCNH2 (0.56) | KCNH2KDRFYNCYP11B2LTA4H | |
| SCHEMBL24137788 | 0.75 | KCNH2 (0.52) | KCNH2LMNAKDRFYNCYP11B2 | |
| SCHEMBL30596229 | 0.75 | KCNH2 (0.52) | KCNH2LMNAKDRFYNCYP11B2 | |
| SCHEMBL5703531 | 0.74 | CCNE1 (0.58) | KDRCCNE1CDK2CDK5NAMPT | |
| SCHEMBL30596228 | 0.74 | PIK3C3 (0.48) | KCNH2KDRFYNCYP11B2LTA4H | |
| SCHEMBL24137484 | 0.74 | PIK3C3 (0.48) | KCNH2KDRFYNCYP11B2LTA4H | |
| SCHEMBL13513650 | 0.73 | KDR (0.66) | LMNAKDRCCNE1CDK2CDK5 | |
| SCHEMBL4932096 | 0.72 | KCNH2 (0.53) | KCNH2KDRFYNCYP11B2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263129-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-30 | — | — | WO | disclosed |