Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.68 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.65 |
| ▸ | STAT3 | P40763 | 2/20 | 0.63 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.61 |
| ▸ | IL1B | P01584 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29403109 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL19451294 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL29403026 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL21814694 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL19451416 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL23884378 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL17873760 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL23884163 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL22280101 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL29856029 | 1.00 | CRBN (0.68) | CRBNDDB1HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262693-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-12-30 | — | — | WO | disclosed |