Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.65 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 10/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28339005 | 0.94 | STAT3 (0.65) | STAT3MAP1LC3BAXLCRBNDYRK2 | |
| SCHEMBL30437920 | 0.94 | STAT3 (0.65) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL28970883 | 0.94 | STAT3 (0.65) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL21596985 | 0.92 | STAT3 (0.62) | STAT3MAP1LC3BAXLCRBNDYRK2 | |
| SCHEMBL21294451 | 0.91 | STAT3 (0.66) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL21303980 | 0.91 | STAT3 (0.66) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL21332800 | 0.91 | STAT3 (0.66) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL30996464 | 0.91 | STAT3 (0.66) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL21304422 | 0.90 | STAT3 (0.65) | STAT3MAP1LC3BAXLCRBN | |
| SCHEMBL21070007 | 0.89 | STAT3 (0.71) | STAT3MAP1LC3BAXLCRBNDYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262693-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-12-30 | — | — | WO | disclosed |