Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.51 |
| ▸ | JAK3 | P52333 | 12/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20513 | 0.81 | JAK2 (0.55) | JAK2JAK3PTK2TP53MAPT | |
| SCHEMBL20626 | 0.81 | JAK2 (0.59) | JAK2JAK3PTK2 | |
| SCHEMBL20266 | 0.79 | JAK2 (0.55) | JAK2JAK3PTK2MAPTAURKA | |
| SCHEMBL21597 | 0.79 | JAK2 (0.59) | JAK2JAK3PTK2AURKAMAPK10 | |
| SCHEMBL16394348 | 0.78 | JAK2 (0.63) | JAK2JAK3PTK2 | |
| SCHEMBL20703 | 0.78 | JAK2 (0.51) | JAK2JAK3PTK2TP53MAPT | |
| SCHEMBL20593 | 0.77 | JAK2 (0.52) | JAK2JAK3PTK2TP53MAPT | |
| SCHEMBL20504 | 0.77 | JAK2 (0.74) | JAK2JAK3PTK2AURKAMAPK10 | |
| SCHEMBL15210529 | 0.77 | JAK2 (0.55) | JAK2JAK3PTK2MAPT | |
| SCHEMBL25496 | 0.77 | JAK2 (0.54) | JAK2JAK3PTK2AURKAMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |