Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | POLRMT | O00411 | 1/20 | 0.30 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25012943 | 0.94 | CYP3A4 (0.38) | CYP3A4CYP2C9POLRMTBTN3A1 | |
| SCHEMBL24148975 | 0.94 | BTN3A1 (0.35) | DOT1LCYP3A4CYP2C9POLRMTBTN3A1 | |
| SCHEMBL24148771 | 0.93 | CYP3A4 (0.34) | DOT1LCYP3A4CYP2C9POLRMTBTN3A1 | |
| SCHEMBL25013555 | 0.93 | DOT1L (0.32) | DOT1LCYP3A4CYP2C9POLRMT | |
| SCHEMBL24149679 | 0.92 | DOT1L (0.33) | DOT1LCYP3A4CYP2C9BTN3A1 | |
| SCHEMBL24148931 | 0.92 | DOT1L (0.33) | DOT1LCYP3A4CYP2C9 | |
| SCHEMBL24148756 | 0.91 | DOT1L (0.32) | DOT1LCYP3A4CYP2C9BTN3A1 | |
| SCHEMBL24149577 | 0.91 | DOT1L (0.33) | DOT1LCYP3A4CYP2C9 | |
| SCHEMBL24148691 | 0.91 | DOT1L (0.34) | DOT1LCYP3A4CYP2C9 | |
| SCHEMBL25012770 | 0.91 | DOT1L (0.33) | DOT1LCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262826-A2 | 1'-CYANO NUCLEOSIDE ANALOGS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2021-12-30 | — | — | WO | disclosed |