Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 18/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.48 |
| ▸ | KIT | P10721 | 7/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574068 | 0.84 | KDR (0.52) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL29736768 | 0.84 | KDR (0.52) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL14447156 | 0.83 | FYN (0.58) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL573861 | 0.81 | KDR (0.50) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL16060927 | 0.81 | CSF1R (0.56) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL5339036 | 0.81 | KDR (0.58) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL27299257 | 0.81 | CSF1R (0.51) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL29736898 | 0.80 | CSF1R (0.50) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL572996 | 0.80 | CSF1R (0.50) | KDRCSF1RPDGFRAKITPDGFRB | |
| SCHEMBL27866390 | 0.80 | CSF1R (0.50) | KDRCSF1RPDGFRAKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365752-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, Llc (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010051373-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | WO | disclosed |