Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 11/20 | 0.47 |
| ▸ | DRD3 | P35462 | 10/20 | 0.47 |
| ▸ | DRD4 | P21917 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18045984 | 0.82 | HDAC6 (0.50) | HRH4DRD2DRD3DRD4MEN1 | |
| SCHEMBL29608130 | 0.82 | HDAC6 (0.50) | HRH4DRD2DRD3DRD4MEN1 | |
| SCHEMBL18045982 | 0.82 | HDAC6 (0.50) | HRH4DRD2DRD3DRD4MEN1 | |
| SCHEMBL6782457 | 0.77 | HRH4 (0.63) | HRH4DRD2DRD3DRD4HTR1A | |
| SCHEMBL30041257 | 0.77 | HRH4 (0.63) | HRH4DRD2DRD3DRD4SLC6A4 | |
| SCHEMBL29208521 | 0.76 | CDK4 (0.50) | MEN1KMT2AADRA2C | |
| SCHEMBL6792453 | 0.75 | DRD4 (0.64) | HRH4DRD2DRD3DRD4KMT2A | |
| SCHEMBL30041328 | 0.74 | HRH4 (0.69) | HRH4DRD2DRD3DRD4HTR1A | |
| SCHEMBL8682915 | 0.74 | HRH4 (0.69) | HRH4DRD2DRD3DRD4HTR1A | |
| SCHEMBL28962397 | 0.74 | HRH4 (0.57) | HRH4DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3932914-A1 | ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS | Valo Health, Inc. (US) | 2022-01-05 | — | — | EP | disclosed |