Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPR1 | P16066 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24167142 | 0.72 | GSK3B (0.44) | TP53CYP1A2CYP3A4PKMNPR1 | |
| SCHEMBL30037687 | 0.66 | NOTUM (0.46) | TSHRITGB2ICAM1ITGALNOTUM | |
| SCHEMBL14288740 | 0.66 | NOTUM (0.46) | TSHRITGB2ICAM1ITGALNOTUM | |
| SCHEMBL30371840 | 0.65 | BLM (1.00) | TP53CYP1A2CYP3A4PKMNPR1 | |
| SCHEMBL29404564 | 0.65 | BLM (1.00) | TP53CYP1A2CYP3A4PKMNPR1 | |
| Hydrochloric Acid SCHEMBL30986586 | 0.65 | NOTUM (0.45) | TSHRITGB2ICAM1ITGALNOTUM | |
| SCHEMBL1485670 | 0.63 | PIK3CA (0.48) | TSHRTHRBITGB2ICAM1ITGAL | |
| SCHEMBL12142431 | 0.62 | NOTUM (0.43) | TSHRITGB2ICAM1ITGALNOTUM | |
| SCHEMBL14108085 | 0.62 | NOTUM (0.46) | TP53TSHRTHRBITGB2ICAM1 | |
| SCHEMBL21729155 | 0.61 | KMT2A (0.45) | TSHRNOTUMSCD5KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022005898-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |