Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.48 |
| ▸ | JAK1 | P23458 | 14/20 | 0.48 |
| ▸ | TYK2 | P29597 | 14/20 | 0.48 |
| ▸ | JAK3 | P52333 | 14/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436566 | 0.83 | JAK2 (0.62) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19436506 | 0.83 | JAK2 (0.62) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19436514 | 0.79 | KDM4E (0.56) | JAK2JAK1TYK2JAK3ADORA2A | |
| SCHEMBL24467536 | 0.78 | ADORA2A (0.42) | JAK2JAK1TYK2JAK3ADORA2A | |
| Bromide SCHEMBL23227960 | 0.78 | KDM4E (0.55) | JAK2JAK1TYK2JAK3ADORA2A | |
| SCHEMBL19437515 | 0.78 | KMT2A (0.63) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL22121361 | 0.77 | KMT2A (0.54) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19436552 | 0.77 | PTGER4 (0.56) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19436475 | 0.76 | BACE1 (0.46) | JAK2JAK1TYK2JAK3ADORA2A | |
| SCHEMBL19451692 | 0.76 | ADORA2A (0.52) | JAK2JAK1TYK2JAK3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002077-A1 | ARYL AROMATIC HETEROCYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2022-01-06 | — | — | WO | disclosed |