Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 12/20 | 0.42 |
| ▸ | GSK3B | P49841 | 8/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24174549 | 0.80 | PLK4 (0.58) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL28978678 | 0.78 | PAK4 (0.43) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL4016823 | 0.78 | PLK4 (0.55) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL30147253 | 0.75 | AURKA (0.70) | PAK4PLK4AURKAGSK3BSRC | |
| SCHEMBL785406 | 0.75 | AURKA (0.70) | PAK4PLK4AURKAGSK3BSRC | |
| SCHEMBL22055000 | 0.75 | PIK3C3 (0.48) | PAK4PLK4HTTKMT2AAURKA | |
| SCHEMBL22054562 | 0.74 | AURKA (0.71) | PAK4PLK4AURKAGSK3BSRC | |
| SCHEMBL30147254 | 0.74 | AURKA (0.71) | PAK4PLK4AURKAGSK3BSRC | |
| SCHEMBL14606095 | 0.73 | PAK1 (0.60) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL30147226 | 0.73 | PAK1 (0.60) | PAK4PLK4MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002118-A1 | FUSED-RING HETEROCYCLE DERIVATIVE AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2022-01-06 | — | — | WO | disclosed |