Butibufen

Butibufen

SCHEMBL24177

CCC(C(=O)O)c1ccc(CC(C)C)cc1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.73
PTGS2 P35354 4/20 0.73
ALOX5 P09917 3/20 0.66
LMNA P02545 2/20 0.66
CYP2C9 P11712 2/20 0.66
AKR1C3 P42330 2/20 0.66
CXCR1 P25024 2/20 0.66
CXCR2 P25025 2/20 0.66
ALB P02768 1/20 0.66
ESR1 P03372 1/20 0.66
RARB P10826 1/20 0.66
ADRB3 P13945 1/20 0.66
NFKB1 P19838 1/20 0.66
HTR2A P28223 1/20 0.66
NR1I3 Q14994 1/20 0.66
SLC22A6 Q4U2R8 1/20 0.66
CXCL8 P10145 1/20 0.66
TSHR P16473 1/20 0.66
AKR1C2 P52895 1/20 0.66
BLM P54132 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butibufen SCHEMBL7346774 1.00 PTGS1 (0.73) PTGS1PTGS2ALOX5LMNACYP2C9
Butibufen SCHEMBL1605646 0.98 PTGS1 (0.71) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL27934588 0.86 PTGS1 (0.69) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL10443322 0.86 PTGS1 (0.59) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL12608939 0.86 ESR1 (0.59) PTGS1PTGS2ALOX5LMNACYP2C9
Butibufen SCHEMBL11729847 0.85 PTGS1 (0.55) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL1574429 0.84 AKR1C3 (0.58) PTGS1PTGS2LMNACYP2C9AKR1C3
SCHEMBL9474541 0.84 PTGS1 (0.71) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL8813286 0.84 PTGS1 (0.71) PTGS1PTGS2ALOX5LMNACYP2C9
SCHEMBL27810576 0.84 PTGS1 (1.00) PTGS1PTGS2ALOX5LMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4378 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119385285-A Fungus flavor enhancer and preparation method thereof 河南伏牛百菌园生物科技有限公司 2025-02-07 CN claimed
EP-4470565-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT OnQuality Pharmaceuticals China Ltd. (CN) 2024-12-04 EP claimed
CN-119033023-A Hydrolyzed protein goat milk-based formula food and preparation method thereof 黑龙江飞鹤乳业有限公司 2024-11-29 CN claimed
US-RE50218-E1 Non-steroidal anti-inflammatory ophthalmic compositions SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2024-11-26 US claimed
US-20240335390-A9 PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS SOLID DISPERSIONS AND METHODS OF PREPARATION THEREOF SHENZHEN PHARMACIN CO LTD (CN) 2024-10-10 US claimed
CN-118742325-A Methods for preventing or treating diseases or conditions associated with antineoplastic agents 上海岸阔医药科技有限公司 2024-10-01 CN claimed
WO-2024105529-A1 CHEMICAL DISBUDDING OF LIVESTOCK MASSEY UNIVERSITY (NZ) 2024-05-23 WO claimed
US-20240148731-A1 PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS SOLID DISPERSIONS AND METHODS OF PREPARATION THEREOF Shenzhen Pharmacin Co., Ltd. (CN) 2024-05-09 US claimed
US-20240041935-A1 PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-02-08 US claimed
WO-2023142996-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT 上海岸阔医药科技有限公司 2023-08-03 WO claimed
EP-0633770-A1 CAPSULE FILLED WITH A MIXTURE OF ACTIVE INGREDIENT IN POWDER FORM AND HIGHLY DISPERSED SILICON DIOXIDE MERCK PATENT GmbH (DE) 1995-01-18 EP claimed
WO-1994020072-A1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF PHARMACIA AB (SE) 1994-09-15 WO claimed
WO-1994017787-A1 CAPSULE FILLED WITH A MIXTURE OF ACTIVE INGREDIENT IN POWDER FORM AND HIGHLY DISPERSED SILICON DIOXIDE MERCK PATENT GMBH (DE) 1994-08-18 WO claimed
EP-0452908-A2 Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids ABBOTT LABORATORIES (US) 1991-10-23 EP claimed
US-5032588-A Non-steroidal antiinflammatory ABBOTT LABORATORIES (US) 1991-07-16 US claimed
WO-1991008744-A1 THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS ABBOTT LABORATORIES (US) 1991-06-27 WO claimed
EP-0374602-A1 Lipoxygenase inhibiting compounds ABBOTT LABORATORIES (US) 1990-06-27 EP claimed
US-4381313-A Phenylalkanoic compounds and therapeutic use thereof HOMMEL AG (CH) 1983-04-26 US claimed
US-4186270-A CHLOROMETHYLATION, CONVERSION TO NITRILE, METHYLATION OR ETHYLATION, HYDROLYSIS THE DOW CHEMICAL COMPANY (US) 1980-01-29 US claimed
US-4031243-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC JUSTE, S.A. QUIMICO-FARMACEUTICA (ES) 1977-06-21 US claimed