Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.58 |
| ▸ | VKORC1 | Q9BQB6 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | PCSK7 | Q16549 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NQO1 | P15559 | 3/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354624 | 0.85 | CYP2C9 (0.69) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL7349467 | 0.83 | CYP2C9 (0.61) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL14078666 | 0.79 | NQO1 (0.69) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL9206009 | 0.79 | NQO1 (0.66) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL5107449 | 0.78 | NQO1 (0.58) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL8623500 | 0.77 | CYP2C9 (0.62) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL7077171 | 0.76 | NQO1 (0.51) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL10638322 | 0.76 | NQO1 (0.73) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL1647627 | 0.75 | NQO1 (0.64) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 | |
| SCHEMBL10338525 | 0.75 | CYP2C9 (0.70) | CYP2C9VKORC1ALDH1A1PCSK7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110236885-A1 | Genetic Variants Predicting Warfarin Sensitivity | ACADEMIA SINICA (TW) | 2011-09-29 | — | — | US | disclosed |
| EP-2246445-A1 | Genetic variants of VKORC1 predicting warfarin sensitivity | Academia Sinica (TW) | 2010-11-03 | — | — | EP | disclosed |
| EP-1831402-B1 | GENETIC VARIANTS OF VKORC1 PREDICTING WARFARIN SENSITIVITY | ACADEMIA SINICA (TW) | 2010-06-09 | — | — | EP | disclosed |
| US-20070298426-A1 | WARFARIN DOSAGE PREDICTION | ACADEMIA SINICA (TW) | 2007-12-27 | — | — | US | disclosed |
| EP-1831402-A2 | GENETIC VARIANTS OF VKORC1 PREDICTING WARFARIN SENSITIVITY | Academia Sinica (TW) | 2007-09-12 | — | — | EP | disclosed |
| US-20060166239-A1 | Genetic variants predicting warfarin sensitivity | ACADEMIA SINICA (TW) | 2006-07-27 | — | — | US | disclosed |
| WO-2006069339-A2 | GENETIC VARIANTS OF VKORCI PREDICTING WARFARIN SENSITIVITY | ACADEMIA SINICA (TW) | 2006-06-29 | — | — | WO | disclosed |
| US-20010041737-A1 | Enhancing the toxicity of warfarin in rodents | RECKITT BENCKISER INC., DELAWARE CORPORATION | 2001-11-15 | — | — | US | disclosed |
| US-6248730-B1 | MIXING TETRACYCLINE OR SALT TO WARFARIN-CONTAINING RODENTICIDAL BAIT TO INHIBIT BACTERIA PRESENT IN THE GASTROINTESTINAL TRACT OF A RODENT AND REDUCE DRUG RESISTANCE | RECKITTT BENCKISER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0682663-B1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | UPJOHN CO (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-1061801-A1 | ENHANCING THE TOXICITY OF WARFARIN IN RODENTS | Reckitt Benckiser Inc. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045778-A1 | ENHANCING THE TOXICITY OF WARFARIN IN RODENTS | RECKITT BENCKISER INC. (US) | 1999-09-16 | — | — | WO | disclosed |
| EP-0758327-A1 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-19 | — | — | EP | disclosed |
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1994018188-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | THE UPJOHN COMPANY (US) | 1994-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041737-A1 | Enhancing the toxicity of warfarin in rodents | VKORC1L1, VKORC1, CYP2E1 | CYP2C9 28/4885VKORC1 2/4885ALDH1A1 682/4885 |
| US-20070298426-A1 | WARFARIN DOSAGE PREDICTION | VKORC1, CYP2C9, VKORC1L1 | CYP2C9 2/4885VKORC1 1/4885ALDH1A1 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.