Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14339932 | 0.93 | ESR2 (0.71) | ESR2ESR1 | |
| SCHEMBL2422236 | 0.89 | ESR2 (0.67) | ESR2ESR1 | |
| SCHEMBL2417960 | 0.88 | ESR2 (0.73) | ESR2ESR1 | |
| SCHEMBL2418485 | 0.88 | ESR2 (0.57) | ESR2ESR1 | |
| SCHEMBL2419980 | 0.88 | ESR2 (0.60) | ESR2ESR1 | |
| SCHEMBL6862469 | 0.86 | ESR2 (0.55) | ESR2ESR1 | |
| SCHEMBL2419324 | 0.85 | ESR2 (0.74) | ESR2ESR1 | |
| SCHEMBL2415354 | 0.84 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL2417755 | 0.84 | ESR2 (0.53) | ESR2ESR1 | |
| SCHEMBL4861051 | 0.83 | ESR2 (0.59) | ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257264-B1 | ESTROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |
| US-7087599-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1257264-A4 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2005-08-10 | — | — | EP | disclosed |
| US-20050137192-A1 | Estrogen receptor modulators | PARKER DANN R JR (US) | 2005-06-23 | — | — | US | disclosed |
| US-6800785-B1 | ALKYLATING INDANONE TO YIELD INTERMEDIATE, ADDING NUCLEOPHILE TO YIELD DIENE, CYCLIZING DIENE VIA RING CLOSING OLEFIN METATHESIS REACTION TO YIELD ALLYLIC ALCOHOL, REARRANGING VIA ALLYLIC OXIDATIVE REARRANGEMENT TO YIELD ENE ONE, DEPROTECTING | MERCK & CO., INC. | 2004-10-05 | — | — | US | disclosed |
| US-20030027840-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2003-02-06 | — | — | US | disclosed |
| EP-1257264-A1 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001082923-A1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030027840-A1 | Estrogen receptor modulators | GPER1, ESR2, ESRRA | ESR2 2/4885ESR1 5/4885 |
| US-20050137192-A1 | Estrogen receptor modulators | GPER1, ESR2, ESRRA | ESR2 2/4885ESR1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.