Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 8/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 8/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187362 | 0.77 | RPS6KA2 (0.56) | RPS6KA3HRH3RPS6KA2MAPKAPK2PARP1 | |
| SCHEMBL19187485 | 0.77 | HRH3 (0.52) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL7167059 | 0.77 | RPS6KA3 (0.53) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL19252882 | 0.74 | RPS6KA3 (0.56) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL2160684 | 0.74 | HRH3 (0.54) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL9573820 | 0.73 | HRH3 (0.39) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL5359531 | 0.71 | HRH3 (0.46) | RPS6KA3HRH3RPS6KA2CYP2D6 | |
| SCHEMBL5359538 | 0.71 | HRH3 (0.46) | RPS6KA3HRH3RPS6KA2CYP2D6 | |
| SCHEMBL1393632 | 0.71 | RPS6KA3 (0.53) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 | |
| SCHEMBL30172384 | 0.71 | RPS6KA3 (0.53) | RPS6KA3HRH3RPS6KA2CYP2D6MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115720578-A | Tricyclic derivative, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2022007866-A1 | FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |