Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.54 |
| ▸ | PIK3R2 | O00459 | 20/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 20/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.54 |
| ▸ | PIK3R5 | Q8WYR1 | 20/20 | 0.54 |
| ▸ | PIK3R3 | Q92569 | 20/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24188783 | 0.86 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL24188762 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL30308338 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL29515405 | 0.84 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL29515240 | 0.76 | PIK3CD (0.62) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL29515266 | 0.75 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL30460541 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL29515155 | 0.73 | PIK3CD (0.58) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| Roginolisib SCHEMBL29515379 | 0.70 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| Roginolisib SCHEMBL12849 | 0.70 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022007924-A1 | OXA-AZABICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2022-01-13 | — | — | WO | disclosed |