Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 8/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31302322 | 1.00 | PRKDC (0.53) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL8871292 | 0.88 | PRKDC (0.50) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30979878 | 0.87 | MAP4K4 (0.44) | PRKDCL3MBTL1 | |
| SCHEMBL14909185 | 0.78 | MAPT (0.50) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3371639 | 0.78 | MAPK10 (0.46) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2419432 | 0.78 | MAPK10 (0.51) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4313377 | 0.77 | SLC6A4 (0.65) | KCNH2 | |
| SCHEMBL30824500 | 0.75 | MAPK10 (0.55) | MAPK10MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21178283 | 0.74 | PRKDC (0.48) | PRKDCMAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL27389897 | 0.73 | IP6K1 (0.53) | PRKDCPIK3CDPIK3CAEGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-A1 | MORPHOLINYLQUINAZOLINES | Merck Patent GmbH (DE) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |