Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24192814 | 0.84 | NR1H2 (0.58) | NR1H2DDR1KDM4EALDH1A1 | |
| SCHEMBL2435935 | 0.83 | NR1H2 (0.70) | NR1H2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL30900087 | 0.83 | NR1H2 (0.70) | NR1H2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL15688033 | 0.81 | NR1H2 (0.60) | NR1H2CHRM1CCNCCDK8KDM4E | |
| SCHEMBL274890 | 0.79 | NR1H2 (0.69) | NR1H2DDR1CHRM1KDM4EALDH1A1 | |
| SCHEMBL29958956 | 0.79 | NR1H2 (0.69) | NR1H2DDR1CHRM1KDM4EALDH1A1 | |
| SCHEMBL27088110 | 0.79 | NR1H2 (0.64) | NR1H2PDE3BPDE3ADDR1KDM4E | |
| SCHEMBL24565655 | 0.78 | NR1H2 (0.64) | NR1H2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL24192809 | 0.77 | NR1H2 (0.66) | NR1H2DDR1CHRM1KDM4EALDH1A1 | |
| SCHEMBL15687979 | 0.76 | NR1H2 (0.61) | NR1H2MAP4K4DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022008383-A1 | ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES | GALAPAGOS NV (BE) | 2022-01-13 | — | — | WO | disclosed |