Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196484 | 0.86 | CYP17A1 (0.54) | CYP17A1ABCB1EGLN2POLB | |
| SCHEMBL29583356 | 0.81 | CYP17A1 (0.59) | CYP17A1ABCB1EGLN2ABCC1MAP4K4 | |
| SCHEMBL29834708 | 0.80 | CYP17A1 (0.53) | CYP17A1SYKRXFP1LMNAPOLB | |
| SCHEMBL2363945 | 0.80 | CYP17A1 (0.53) | CYP17A1SYKRXFP1LMNAPOLB | |
| SCHEMBL8166208 | 0.78 | CYP17A1 (0.55) | CYP17A1SYKABCB1EGLN2ABCC1 | |
| SCHEMBL31307614 | 0.76 | CYP17A1 (0.56) | CYP17A1ABCB1EGLN2 | |
| SCHEMBL15925258 | 0.76 | CYP17A1 (0.54) | CYP17A1RXFP1LMNA | |
| SCHEMBL857284 | 0.76 | HTT (0.55) | CYP17A1LMNAPOLB | |
| SCHEMBL7347458 | 0.75 | CYP17A1 (0.55) | CYP17A1ABCB1EGLN2GSK3BDYRK1A | |
| SCHEMBL14512376 | 0.75 | CYP17A1 (0.50) | CYP17A1ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |