SCHEMBL24200569

SCHEMBL24200569

CCOc1cccc2c1C(=O)c1c(OCC)cc(NC(=O)CC)cc1C2=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.53
KMT2A Q03164 4/20 0.52
ALDH1A1 P00352 4/20 0.52
MAPT P10636 3/20 0.52
POLB P06746 3/20 0.52
MEN1 O00255 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
RAB9A P51151 2/20 0.52
NPC1 O15118 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
NPSR1 Q6W5P4 1/20 0.44
CASP3 P42574 2/20 0.42
ELANE P08246 2/20 0.42
KDM4E B2RXH2 1/20 0.41
ABCC4 O15439 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16921392 0.92 TTR (0.52) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16919798 0.91 TTR (0.51) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16921394 0.91 TTR (0.51) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL21657806 0.91 MAPT (0.50) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16921390 0.91 TTR (0.51) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16921391 0.91 TTR (0.51) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16921387 0.90 TTR (0.50) TTRKMT2AALDH1A1MAPTPOLB
SCHEMBL16921386 0.88 TTR (0.48) TTRALDH1A1MAPTSMN1; SMN2NPSR1
SCHEMBL21657777 0.87 KMT2A (0.53) KMT2AALDH1A1MAPTPOLBMEN1
SCHEMBL16921393 0.85 TTR (0.50) TTRKMT2AALDH1A1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2872474-B1 ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF UNIV GEORGIA STATE RES FOUND (US) 2022-01-19 EP disclosed