Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 5/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761276 | 0.88 | MKNK1 (0.59) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL23761645 | 0.85 | MKNK1 (0.48) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL23761543 | 0.82 | MKNK1 (0.58) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL23761590 | 0.81 | MKNK1 (0.56) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL23761512 | 0.77 | MKNK1 (0.78) | EIF4EMKNK1MKNK2SMN1; SMN2MAP4K4 | |
| SCHEMBL23761632 | 0.77 | MKNK1 (0.57) | EIF4EMKNK1MKNK2 | |
| SCHEMBL23761438 | 0.76 | MKNK1 (0.72) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL23761414 | 0.76 | SRD5A1 (0.45) | EIF4EMKNK1MKNK2SRD5A1KDM4E | |
| SCHEMBL20505797 | 0.75 | MKNK1 (0.58) | EIF4EMKNK1MKNK2ADORA3ADORA2A | |
| SCHEMBL20506321 | 0.75 | MKNK1 (0.58) | EIF4EMKNK1MKNK2ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |