Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.45 |
| ▸ | EIF4E | P06730 | 6/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761435 | 0.90 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761323 | 0.89 | MKNK1 (0.48) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761212 | 0.88 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMKCNQ2 | |
| SCHEMBL23761308 | 0.88 | MKNK1 (0.48) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761391 | 0.86 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMEGFR | |
| SCHEMBL23761345 | 0.85 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMKIT | |
| SCHEMBL23761515 | 0.85 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761447 | 0.84 | MKNK1 (0.41) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761492 | 0.84 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMROCK1 | |
| SCHEMBL23761495 | 0.83 | MKNK1 (0.55) | MKNK1MKNK2EIF4ENOTUMROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |