Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | GPER1 | Q99527 | 3/20 | 0.72 |
| ▸ | GPR183 | P32249 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701119 | 0.87 | MAPT (0.81) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700906 | 0.86 | MAPT (0.78) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12722301 | 0.85 | MAPT (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL916774 | 0.84 | MAPT (0.73) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700921 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700948 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700947 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12524898 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700983 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL12700922 | 0.84 | GPER1 (1.00) | MAPTL3MBTL1TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236074-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-02-01 | — | — | US | disclosed |
| US-20220017497-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | UNIV PENNSYLVANIA (US) | 2022-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236074-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | MC1R, GPER1, NR2E3 | MAPT 4810/4885L3MBTL1 4658/4885TDP1 3691/4885 |
| US-20220017497-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | MC1R, GPER1, NR2E3 | MAPT 4810/4885L3MBTL1 4658/4885TDP1 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.