Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22027940 | 0.90 | EGFR (0.81) | EGFRALK | |
| SCHEMBL24207268 | 0.90 | EGFR (0.83) | EGFR | |
| SCHEMBL25370512 | 0.87 | EGFR (0.78) | EGFR | |
| SCHEMBL29257993 | 0.86 | EGFR (0.67) | EGFR | |
| SCHEMBL29877372 | 0.84 | EGFR (0.69) | EGFR | |
| SCHEMBL29257807 | 0.84 | EGFR (0.69) | EGFR | |
| SCHEMBL23420378 | 0.83 | EGFR (0.56) | EGFR | |
| SCHEMBL24207420 | 0.82 | EGFR (0.59) | EGFR | |
| SCHEMBL22028077 | 0.82 | EGFR (0.76) | EGFRALK | |
| SCHEMBL25144549 | 0.82 | EGFR (0.69) | EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012622-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |