Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 7/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB27A | P51159 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | PDE6A | P16499 | 2/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22163831 | 0.92 | PIK3CB (0.46) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL24211056 | 0.92 | PIK3CB (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23965975 | 0.90 | PIK3CB (0.40) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23965982 | 0.89 | PIK3CB (0.49) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23965967 | 0.88 | PIK3CB (0.39) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL24211091 | 0.86 | PIK3CB (0.45) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23966148 | 0.86 | PIK3CB (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23966027 | 0.86 | KMT2A (0.36) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23966018 | 0.85 | PIK3CB (0.49) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 | |
| SCHEMBL23966057 | 0.85 | PIK3CB (0.45) | PIK3CBPIK3CDPIK3CAPIK3CGCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017505-A1 | AMINOQUINAZOLINONE AND AMINOISOQUINOLINONE DERIVATIVES AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017505-A1 | AMINOQUINAZOLINONE AND AMINOISOQUINOLINONE DERIVATIVES AND APPLICATION THEREOF | PIK3R5, PIK3CA, PIK3R1 | PIK3CB 9/4885PIK3CD 4/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.