SCHEMBL24225013

SCHEMBL24225013

C=CC(=O)Nc1ccccc1Nc1ncc2c(n1)N(CC(F)F)C(=O)N(c1cc(C)cc(OC)c1)C2

nearest known ligand 0.71

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ FGFR4 P22455 20/20 0.71
▸ FGFR1 P11362 5/20 0.71
▸ FGFR2 P21802 5/20 0.71
▸ FGFR3 P22607 5/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16137301 0.96 FGFR4 (0.77) FGFR4FGFR1FGFR2FGFR3
SCHEMBL23653016 0.92 FGFR4 (0.69) FGFR4FGFR1FGFR2FGFR3
SCHEMBL24225037 0.91 FGFR4 (0.74) FGFR4FGFR1FGFR2FGFR3
SCHEMBL23653040 0.91 FGFR4 (0.73) FGFR4FGFR1FGFR2FGFR3
SCHEMBL24224903 0.90 FGFR4 (0.75) FGFR4FGFR1FGFR2FGFR3
SCHEMBL17522148 0.89 FGFR4 (0.84) FGFR4FGFR1FGFR2FGFR3
SCHEMBL24225047 0.88 FGFR4 (0.64) FGFR4FGFR1FGFR2FGFR3
SCHEMBL16133983 0.87 FGFR4 (0.75) FGFR4FGFR1FGFR2FGFR3
SCHEMBL23653204 0.86 FGFR4 (0.84) FGFR4FGFR1FGFR2FGFR3
SCHEMBL16071614 0.86 FGFR4 (0.72) FGFR4FGFR1FGFR2FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3943087-A1 HETEROARYL COMPOUNDS AND USES THEREOF Celgene CAR LLC (BM) 2022-01-26 — — EP disclosed
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