Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24239299 | 0.89 | HDAC6 (0.33) | PPARGDRD1 | |
| SCHEMBL24239300 | 0.82 | BRAF (0.38) | KCNH2 | |
| SCHEMBL29052745 | 0.81 | — | — | |
| SCHEMBL24229492 | 0.78 | HRH3 (0.44) | ABCB1HRH1CYP2D6 | |
| SCHEMBL24229708 | 0.77 | HRH3 (0.43) | HRH1CYP2D6 | |
| SCHEMBL24229758 | 0.77 | HRH3 (0.47) | HRH1CYP2D6 | |
| SCHEMBL24229635 | 0.75 | HRH3 (0.41) | HRH1CYP2D6 | |
| SCHEMBL24229632 | 0.74 | HDAC6 (0.37) | PPARGDRD1DRD5ABCC1 | |
| SCHEMBL24229760 | 0.74 | — | — | |
| SCHEMBL29052787 | 0.68 | RAF1 (0.33) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022023447-A2 | FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2022-02-03 | — | — | WO | disclosed |