Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | NRAS | P01111 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231490 | 0.90 | FLT3 (0.50) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24574020 | 0.90 | FLT3 (0.49) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24231687 | 0.88 | CCNT1 (0.45) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24231686 | 0.86 | IRAK4 (0.62) | FLT3IRAK4CCNT1USP30IRAK1 | |
| SCHEMBL24231434 | 0.86 | FLT3 (0.51) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24231547 | 0.85 | FLT3 (0.46) | FLT3IRAK4USP30IRAK1LCK | |
| SCHEMBL19918240 | 0.85 | FLT3 (0.51) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24574190 | 0.85 | FLT3 (0.51) | FLT3IRAK4IDH1CCNT1USP30 | |
| SCHEMBL24231865 | 0.84 | IRAK4 (0.56) | FLT3IRAK4CCNT1USP30 | |
| SCHEMBL24574159 | 0.84 | FLT3 (0.51) | FLT3IRAK4IDH1CCNT1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026935-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-02-03 | — | — | WO | disclosed |